2-PHENYL-BENZIMIDAZOL AND 2-PHENYL-IMIDAZO-`4,5!-PYRIDINE DERIVATIVES AS CHECKPOINT KINASE CDS1 (CHK2) INHIBITORS FOR THE TREATMENT OF CANCER,申请号WO2004US11775-传众专利搜索

2-PHENYL-BENZIMIDAZOL AND 2-PHENYL-IMIDAZO-`4,5!-PYRIDINE DERIVATIVES AS CHECKPOINT KINASE CDS1 (CHK2) INHIBITORS FOR THE TREATMENT OF CANCER

申请公布号：WO2004093873(A1)

申请号：WO2004US11775

申请日期：2004.04.16

申请公布日期：2004.11.04

申请人：

JANSSEN PHARMACEUTICA, N.V.;AMERIKS,, MICHAEL, K.;ARIENTI,, KRISTEN, L.;AXE, FRANK, U.;BREITENBUCHER, J., GUY

发明人：AMERIKS,, MICHAEL, K.;ARIENTI,, KRISTEN, L.;AXE, FRANK, U.;BREITENBUCHER, J., GUY

分类号：A61K31/4184;A61K31/454;A61K31/4745;A61P43/00;C07D235/18;C07D401/10;C07D401/12;C07D403/12;C07D405/10;C07D405/12;C07D409/12;C07D471/02;(IPC1-7):A61K31/418

主分类号：A61K31/4184

摘要：<p>2-Phenyl substituted benzimidazoles and imidazo[4,51pyridines of formula (I)are disclosed as inhibitors of Cds1 and useful as adjuvants to chemotherapy or radiation therapy in the treatment of cancer. Wherein W is -COOH, -(CO)NH2, or -(SO2)NH2; Q is N or CH; Z is selected from the group consisting of a) >C=O, >C=CHRf, >CRdRd, >CF2, >CRdORe, >C(ORd)ORe, b) >C(Rd)NRdRg, C) -SO2NRdC(Rh)2-, where A is fuse d at the b or c faces, at a face of A which contains two carbon atoms, which is saturated or unsaturated, where A is fused at the b or c; faces, at a face of A which contains two carbon atoms, which is saturated or unsaturated, d) >NC1-4alkyl, where the alkyl is optionally substituted with a. substituent selected from the group consisting of -NH2, -NHC1-4alkyl, -N(C1-4aIkyl)2, -CONH2, -CONHC1-4alkyl-, -CON(C1-4aIkyl)2, -COOH, --COOC1-4alkyl, -OH and -OC1-4alkyl; A is selected from the group consisting of: a) phenyl or other substituents defined in claim1. The other substituents are as defined in claim1.</p>