Avidin derivatives and uses thereof,申请号US20030624503-传众专利搜索

Avidin derivatives and uses thereof

申请公布号：US2004191832(A1)

申请号：US20030624503

申请日期：2003.07.23

申请公布日期：2004.09.30

申请人：

YEDA RESEARCH AND DEVELOPMENT CO., LTD.

发明人：WILCHEK MEIR;BAYER EDWARD A.;HOFSTETTER HEIKE;MORPURGO MARGHERITA

分类号：A61K31/192;A61K31/195;A61P43/00;C07C235/34;C07C245/08;C07D207/40;C07D273/02;C07K1/00;C07K1/13;C07K14/36;G01N33/53;G01N33/532;G01N33/545;G01N33/552;G01N33/553;(IPC1-7):G01N33/53

主分类号：A61K31/192

摘要：A covalent conjugate of a 4'-hydroxyazobenzene-2-carboxylic acid. derivative (HABA) and an avidin-type molecule, of the formula: wherein A is (CH2)n or -CH=CH-, wherein n is an integer from 0-10; B is (CH2)n wherein n is an integer from 2 to 10; m is zero or 1; and Av is the residue of an avidin-type molecule selected from the group comprising native egg-white avidin, recombinant avidin, deglycosylated avidins, bacterial streptavidin, recombinant streptavidin, truncated streptavidin and other derivatives of said avidin-type molecules. These HABAylated avidins are red colored in the quinone configuration and can be used in many applications in the avidin-biotin technology.