Intermediate release nicotinic acid compositions for treating hyperlipidemia having unique biopharmaceutical characteristics
申请公布号:US6746691(B2)
申请号:US19970962424
申请日期:1997.10.31
申请公布日期:2004.06.08
发明人:CEFALI EUGENIO A.
分类号:A61K9/20;A61K9/22;A61K31/44;A61K31/455;(IPC1-7):A61K9/22
主分类号:A61K9/20
摘要:Intermediate release nicotinic acid formulations having unique biopharmaceutical characteristics, which are suitable for oral administration once per day as a single dose preferably administered during the evening or at night for treating hyperlipidemia without causing drug-induced hepatotoxicity to such a level that requires the therapy to be discontinued, are disclosed. The intermediate nicotinic acid formulations can be administered as tablets in dosage strengths of, for example, 375 mg, 500 mg, 750 mg and 1000 mg. The 375 mg, 500 mg and 750 mg nicotinic acid tablets of the present invention have a dissolution curve similarity fit factor F2 of at least about 79, and the 1000 mg nicotinic acid tablets of the present invention have a dissolution curve similarity fit factor F2 of at least 44.
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