Herpes viruses for immune modulation,申请号US20020273348-传众专利搜索

Herpes viruses for immune modulation

申请公布号：US2004022812(A1)

申请号：US20020273348

申请日期：2002.10.18

申请公布日期：2004.02.05

申请人：

BIOVEX LIMITED

发明人：COFFIN ROBERT S.

分类号：A61K35/76;A61K48/00;C12N5/08;C12N7/01;C12N15/869;(IPC1-7):A61K39/245;A61K39/255;A61K39/265;A61K39/27;C12N7/00

主分类号：A61K35/76

摘要：A method of stimulating an immune response in a human or animal subject, which method comprises administering to a subject in need thereof an effective amount of an attenuated herpes virus which: (i) lacks a functional vhs gene, or a functional equivalent thereof; (ii) lacks a functional ICP47 gene, or a functional equivalent thereof; and (iii) is incapable of expressing a substantial amount of functional ICP22, or a functional equivalent thereof, in mammalian dendritic cells.