Method and composition for treatment of diabetes, hypertension, chronic heart failure and fluid retentive states,申请号US20030421465-传众专利搜索

Method and composition for treatment of diabetes, hypertension, chronic heart failure and fluid retentive states

申请公布号：US2003236272(A1)

申请号：US20030421465

申请日期：2003.04.23

申请公布日期：2003.12.25

申请人：

CARR RICHARD DAVID

发明人：CARR RICHARD DAVID

分类号：A61K45/06;A61K31/00;A61K31/222;A61K31/401;A61K31/426;A61K31/4439;A61K31/522;A61K38/05;A61K45/00;A61P3/02;A61P3/10;A61P7/10;A61P9/00;A61P9/08;A61P9/10;A61P9/12;A61P11/00;A61P13/02;A61P15/00;A61P43/00;C07D277/04;C07D277/30;C07K5/06;C07K5/08;(IPC1-7):A61K31/522

主分类号：A61K45/06

摘要：The present invention is related to a method and composition for treatment of diabetes, hypertension, chronic heart failure and fluid retentive states comprising administering inhibitors of the enzymes NEP and DPP-IV to individuals suffering from one or more of those conditions. Inhibition of the activity of the two enzymes will potentiate the insulin releasing activity of endogenous GLP-1 and other DPP-IV substrates like GIP.