METHOD FOR PLANNING NEUTRON CAPTURE THERAPY,申请号RU20010111347-传众专利搜索

METHOD FOR PLANNING NEUTRON CAPTURE THERAPY

申请公布号：RU2212260(C2)

申请号：RU20010111347

申请日期：2001.04.26

申请公布日期：2003.09.20

申请人：

MEDITSINSKIJ RADIOLOGICHESKIJ NAUCHNYJ TSENTR RAMN

发明人：UL'JANENKO S.E.;KORJAKIN S.N.;JADROVSKAJA V.A.;SAVINA E.P.;GORBUSHIN N.G.

分类号：A61N5/10;A61B6/03

主分类号：A61N5/10

摘要：FIELD: medicine. SUBSTANCE: method involves administering tumorothropic gammaradiation-labeled preparation possessing high cross- section of heat neutron capture. Preparation accumulation and removal dynamics is studied by means of gamma-tomograph device. Time interval is selected for administering neutron capture therapy under condition of where Ctumor(t) and Ctisue(t) - is the high heat neutron capture cross-section chemical element concentration in tumor and surrounding tissues, minCtumor(t) is the minimum high heat neutron capture cross-section chemical element concentration in tumor enabling heat neutron irradiation results in effective absorption dose. Radiation dose power due to neutron capture reaction taking place is calculated. Labeled substance accumulation dynamics is studied from the moment of its administration within 48 h. Dose power is determined from P = Phi.(Ctumor.NA/M).sigma.E.K, where P is the dose power, cGr/s, Phi is the heat neutron flux density, n/sq.cm, NA is the Avogadro number, M is molecular mass of the chemical element having high cross-section of heat neutron capture, sigma is the heat neutron capture cross-section in sq.cm, E is the reaction product energy in MeV, K is the dimension coordination coefficient equal to 1,6.10-8 cGrg/MeV. EFFECT: enhanced effectiveness of treatment planning in the cases of complex malignant tumor forms. 3 cl, 3 dwg, 1 tbl