PALMITYL TRANSFERASES,申请号WO2002EP02424-传众专利搜索

PALMITYL TRANSFERASES

申请公布号：WO02070677(A3)

申请号：WO2002EP02424

申请日期：2002.03.06

申请公布日期：2003.09.12

申请人：

MEMOREC STOFFEL GMBH - MEDIZINISCH-MOLEKULARE ENTWICKLUNG, KOELN;CONRADT, MARKUS;HOFMANN, KAY

发明人：CONRADT, MARKUS;HOFMANN, KAY

分类号：A61P35/00;C12N9/10

主分类号：A61P35/00

摘要：Palmityl transferases with four cysteine radicals in a catalystically active structure, wherein two cysteine radicals are disposed according to the following pattern: RX1X2HCX3X4C and two other cysteine radicals are disposed according to the following pattern: CX5X6X7X8DHHC, wherein X1 is independently selected from T, S, C, A; X2 is independently selected from K, H, S, W, R; X3 is independently selected from G, T, S, N, V, P, C, A; X4 is independently selected from I, T, S, V, R, K, A, L; X5 is independently selected from V, I; X6 is independently selected from H, L, M, E, A, S, G, R; X7 is independently selected from E, R, K, V, T, Y, M; X8 is independently selected from A, H, F, M, R and the patterns RX1X2HCX3X4C and CX5X6X7X8DHHC are disposed between two transmembrane regions.