Slow release pharmaceutical preparation and method of administering same
申请公布号:US2003170305(A1)
申请号:US20030363107
申请日期:2003.05.07
申请公布日期:2003.09.11
发明人:O'NEIL ALEXANDER GEORGE B.;LIU YANDI
分类号:A61K9/00;A61K9/16;A61K9/20;A61K9/26;A61K9/28;A61K9/30;A61K9/50;A61K31/485;A61M37/00;A61P25/36;(IPC1-7):A61K9/26
主分类号:A61K9/00
摘要:A pharmaceutical preparation adopted for sustained release of an active agent(s) over an extended period of time at a therapeutic rate without an initial burst release of the agent(s) upon administration, wherein the preparation comprises: (i) an outer portion prepared from one or more layers of a biodegradable polymer, which is selected to release an active agent over an extended period of time when positioned in situ in a patient, and (ii) an inner portion comprising a plurality of micro-capsules formed from at least a biodegradable polymer, said micro capsules containing at least an active agent, wherein the micro-capsules are compressed into the form of a tablet under suitable pressure to suppress the rate of release of the active agent from the micro-capsules. The present specification also relates to a method for inserting one or more implants(s) into a tissue of a mammal comprising the following steps: a) making a small incision into the tissue with a needle and a first sheath; b) withdrawing the needle from the first sheath but leaving the first sheath in the tissue; c) dilating the opening of the incision by inserting a dilator and second sheath of larger diameter through the body of the first sheath; d) withdrawing the dilator from the second sheath, but leaving the second sheath in the tissue; e) disturbing the implant(s) from a sheath filled with implant(s) by inserting said sheath into the final sheath inserted into the tissue and pushing a dilator into the sheath thereby releasing said implant(s) into the tissue.
Elektronische Auswahlschaltung
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