EPITOPES OR MIMOTOPES DERIVED FROM THE C-EPSILON-2 DOMAIN OF IGE, ANTAGONISTS THEREOF, AND THEIR THERAPEUTIC USES.

申请公布号：MXPA01008613(A)

申请号：MX2001PA08613

申请日期：2000.02.22

申请公布日期：2003.06.24

申请人：

SMITHKLINE BEECHAM BIOLOGICALS S. A.

发明人：FRIEDE, MARTIN

分类号：G01N33/53;A61K38/00;A61K39/00;A61K39/395;A61K45/00;A61K47/48;A61P31/00;A61P37/00;A61P37/08;B01J20/281;C07K7/00;C07K14/02;C07K16/00;C07K16/42;C07K19/00;G01N30/88

主分类号：G01N33/53

摘要：<p>The present invention relates to the provision of novel medicaments for the treatment, prevention or amelioration of allergic disease. In particular, the novel medicaments are isolated peptides incorporating epitopes or mimotopes of surface exposed regions of the Cepsilon2 domain of IgE. The inventors have found that these novel regions may be the target for both passive and active immunoprophylaxis or immunotherapy. The invention further relates to methods for production of the medicaments, pharmaceutical compositions containing them and their use in medicine. Also forming an aspect of the present invention are ligands, especially monoclonal antibodies, which are capable of binding the surface exposed IgE regions of the present invention, and their use in medicine as passive immunotherapy or in immunoprophylaxis.</p>

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