METHOD FOR DETECTING BINDING STATE BETWEEN BIOMOLECULES BY MEASURING SHEAR STRESS,申请号KR20010065484-传众专利搜索

METHOD FOR DETECTING BINDING STATE BETWEEN BIOMOLECULES BY MEASURING SHEAR STRESS

申请公布号：KR20030033486(A)

申请号：KR20010065484

申请日期：2001.10.23

申请公布日期：2003.05.01

申请人：

SAMSUNG ELECTRONICS CO., LTD.

发明人：CHO, YUN GYEONG;KIM, SEON HUI;LIM, GEUN BAE;OH, GWANG UK;YOON, DAE SEONG

分类号：G01L1/00;C12Q1/68;G01N11/16;G01N19/00;G01N27/26;G01N33/483;G01N33/53;G01N33/566;G01N37/00;G01Q60/32;G01Q70/18;(IPC1-7):G01N27/26

主分类号：G01L1/00

摘要：PURPOSE: A method for detecting a binding state between biomolecules is provided to obtain a detecting result as an electric signal by measuring shear stress of a substrate without performing a separate labeling work. CONSTITUTION: Biomolecules of probes are attached to a surface of a substrate. Then, the biomolecules of the probes are reacted with a sample including target biomolecules. Shear stress of the substrate is measured before and after the biomolecules of the probes are reacted with the sample. Shear stress is measured by means of a shear stress measuring sensor(11) based on a phase shift and a force shift of a vibration motion. Biomolecules of the target and the probes include any one selected from the group consisting of DNA oligomer, nucleic acids, such as c-DNA, proteins, cofactors, oligosaccharides, and cell.