Novel tricyclic hydroxy carboxamides and derivatives thereof tocolytic oxytocin receptor antagonists,申请号US20020120100-传众专利搜索

Novel tricyclic hydroxy carboxamides and derivatives thereof tocolytic oxytocin receptor antagonists

申请公布号：US2003018026(A1)

申请号：US20020120100

申请日期：2002.04.10

申请公布日期：2003.01.23

申请人：

WYETH

发明人：ARTURO FAILLI AMEDEO;SHUMSKY JAY SCOTT;CAGGIANO THOMAS JOSEPH;SABATUCCI JOSEPH PETER;MEMOLI KEVIN ANTHONY;TRYBULSKI EUGENE JOHN;SANDERS WILLIAM JENNINGS

分类号：A61K31/5517;A61P1/16;A61P7/02;A61P9/04;A61P9/12;A61P15/00;A61P15/06;A61P15/18;A61P25/18;A61P25/22;A61P27/06;A61P27/10;A61P27/16;A61P43/00;C07D471/14;C07D487/04;(IPC1-7):A61K31/551;C07D487/12

主分类号：A61K31/5517

摘要：This invention provides novel substituted tricyclic carboxamides which act as oxytocin receptor competitive antagonists, as well as methods of their manufacture, pharmaceutical compositions and methods of their use in treatment, inhibition, suppression or prevention of preterm labor, dysmenorrhea and endometritis, suppression of labor at term prior to caesarean delivery, and to facilitate antinatal transport to a medical facility. These compounds are also useful in enhancing fertility rates, enhancing survival rates and synchronizing estrus in farm animals; and may be useful in the prevention and treatment of disfunctions of the oxytocin system in the central nervous system including obsessive compulsive disorder (OCD) and neuropsychiatric disorders.