New camptothecin analogues, preparation methods thereof, use thereof as drugs, and pharmaceutical compositions containing them,申请号EP20020077736-传众专利搜索

New camptothecin analogues, preparation methods thereof, use thereof as drugs, and pharmaceutical compositions containing them

申请公布号：EP1251125(A2)

申请号：EP20020077736

申请日期：1996.06.21

申请公布日期：2002.10.23

申请人：

SOCIETE DE CONSEILS ET DE RECHERCHES D'APPLICATIONS SCIENTIFIQUES (S.C.R.A.S.)

发明人：BIGG, DENNIS;LAVERGNE, OLIVIER;PLA RODAS, FRANCESC;POMMIER, JACQUES;ULIBARRI, GERARD

分类号：A61K31/47;A61K31/4745;A61K31/475;A61K31/496;A61K31/5377;A61P31/12;A61P33/00;A61P33/02;A61P35/00;A61P43/00;C07D209/00;C07D213/02;C07D213/61;C07D213/64;C07D213/66;C07D215/08;C07D221/00;C07D313/00;C07D413/10;C07D471/14;C07D487/04;C07D491/04;C07D491/044;C07D491/22;C07D498/14;(IPC1-7):C07D215/18

主分类号：A61K31/47

摘要：<p>Camptothecin analogues where the camptothecin hydroxy lactone is: (i) a beta -hydroxy lactone; or (ii) the corresp. beta -hydroxy acid resulting from ring-opening of the aforementioned lactone; or a (iii) deriv. of the beta -hydroxy acid in (ii) or its one of its salts. Also claimed are new industrial prods. of formula (M) and (A). R1 = lower alkyl, lower alkenyl, lower alkynyl, halo(lower alkyl), lower alkoxy(lower alkyl) or lower alkylthio(lower alkyl); R20 = H or halo; R22 = F, Cl, or lower alkoxy; R23 = prim. hydroxy-protecting gp.; and R18, R19 = H, halo, lower alkyl, lower alkoxy or OH.</p>