METHOD OF TREATING PAIN USING NALBUPHINE AND OPIOID ANTAGONISTS
申请公布号:WO0193852(A3)
申请号:WO2001US18901
申请日期:2001.06.08
申请公布日期:2002.10.10
发明人:LEVINE, JON, D.
分类号:A61K45/00;A61K31/485;A61P25/02;A61P25/04;A61P29/00
主分类号:A61K45/00
摘要:Inflammatory or neuropathic pain in both men and women patients is treated by administering, sequentially or simultaneously, (a) nalbuphine and (b) an opioid antagonist selected from naloxone, naltrexone and nalmefene, or a salt or prodrug of nalbuphine and/or the opioid antagonist. Preferably, administration is made of (a) an amount of from about 3 to about 8 mg nalbuphine and (b) from about 0.2 to about 0.8 mg of an opioid antagonist selected from naloxone, naltrexone and nalmefene, or a salt and/or prodrug of either (in an amount that produces in a patient the same blood concentration of the compound in question as would administration of said amount of the nalbuphine or opioid antagonist itself).Treatment of both inflammatory and neuropathic pain can be achieved; side effects common with mu -opioids such as morphine were not observed.
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