A one pot process for the preparation of caffeic acid ester derivatives,申请号EP20000310718-传众专利搜索

A one pot process for the preparation of caffeic acid ester derivatives

申请公布号：EP1211237(A1)

申请号：EP20000310718

申请日期：2000.12.01

申请公布日期：2002.06.05

申请人：

MEDICAM CHEMICAL & PHARMACEUTICAL CO., LTD.

发明人：LEE, YEAN-JANG

分类号：C07C67/14;(IPC1-7):C07C67/14;C07C69/732;C07C69/734

主分类号：C07C67/14

摘要：<p>The present invention relates to a one pot process for the preparation of caffeic acid ester derivatives of the formula I: <CHEM> wherein Ar is aryl, which is unsubstituted or substituted with halogen, hydroxy, C1-6 alkyl or C1-6 alkoxy, A is C1-6 alkylene, C2-6 alkenylene or C2-6 alkynylene, m is a number from 0 to 6; and B is C1-6 alkyl or aryl, which is unsubstituted or substituted with halogen, hydroxy, C1-6 alkyl or C1-6 alkoxy; which process comprises reacting, in a suitable solvent for esterification of a carboxylic acid derivative, a compound of the formula II: <CHEM> wherein Ar and A are as defined above. with a halogenating reagent and alcohol of the formula III: H-(CH2)m-B wherein m and B are as defined above.or</p>