PROTEIN LOCALIZATION ASSAYS FOR TOXICITY AND ANTIDOTES THERETO,申请号EP20000939864-传众专利搜索

PROTEIN LOCALIZATION ASSAYS FOR TOXICITY AND ANTIDOTES THERETO

申请公布号：EP1185864(A1)

申请号：EP20000939864

申请日期：2000.06.14

申请公布日期：2002.03.13

申请人：

TRELLIS BIOINFORMATICS INC.

发明人：KAUVAR, LAWRENCE, M.

分类号：G01N33/573;A61K45/00;A61P37/02;C12Q1/48;G01N33/48;G01N33/50;G01N33/53;(IPC1-7):G01N33/50

主分类号：G01N33/573

摘要：Intracellular translocation of proteins, particularly protein kinase C (PKC) isoenzymes, provides a surrogate test system for determining toxicity of candidate compounds. The profile of translocation with respect to at least one and preferably two or more signal transduction proteins can be correlated with that of known toxins. In addition, databases of such profiles with respect to toxins of various types provide a useful set of standards for evaluating toxicity of candidate compounds. Moreover, to the extent that a toxin's profile mimics that found in a diseased state, the toxin can be used to construct screens for compounds alleviating the disease.