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ACYCLIC ETHYLENEDIAMINE DERIVATIVES AS SUBSTANCE P RECEPTOR ANTAGONISTS
申请公布号：CA2123403(C)
申请号：CA19922123403
申请日期：1992.09.18
申请公布日期：2002.02.05
发明人：O'NEILL, BRIAN T.
分类号：A61K31/13;A61K31/135;A61K31/16;A61K31/215;A61K31/35;A61K31/351;A61K31/357;A61K31/36;A61K31/40;A61K31/41;A61K31/42;A61K31/421;A61K31/425;A61K31/426;A61K31/445;A61K31/47;A61P1/00;A61P25/00;A61P25/04;A61P25/18;A61P25/20;A61P25/24;A61P25/26;A61P29/00;A61P37/08;C07C211/18;C07C211/27;C07C211/44;C07C213/00;C07C217/58;C07C229/06;C07C233/36;C07C311/03;C07D209/48;C07D213/38;C07D215/06;C07D215/12;C07D215/14;C07D249/08;C07D257/04;C07D261/08;C07D263/32;C07D275/02;C07D277/28;C07D295/12;C07D295/125;C07D295/13;C07D309/32;C07D317/58;C07D333/20;C07D401/02;C07D403/02;C07D405/02;C07D409/02;C07D413/02;C07D417/02;C07D417/12;(IPC1-7):C07C217/58;A61K31/33;C07D307/52
主分类号：A61K31/13
摘要：The present invention relates to novel acyclic ethylenediamine derivatives o f nitrogen containing heterocyclic compounds, and specifically, to compounds of formula (I) wherein R1, R2, R3, R4, R5 and R6 are defined as in the specification. It also re- lates to novel intermediates used in the synthesis of such derivatives. Compounds of formula (I) and their pharmaceutically acceptable salts are useful in the treatment of inflammatory and central nervous system disorders, as well as other disorders.