REDUCED PARTICLE SIZE FORM OF 1-(6-CHLORONAPHTH-2- YLSULPHONYL)-4-[4-(4PYRIDYL)BENZOYL]PIPERAZINE AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM AND THEIR USE,申请号HU20010002394-传众专利搜索

REDUCED PARTICLE SIZE FORM OF 1-(6-CHLORONAPHTH-2- YLSULPHONYL)-4-[4-(4PYRIDYL)BENZOYL]PIPERAZINE AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM AND THEIR USE

申请公布号：HU0102394(A2)

申请号：HU20010002394

申请日期：1999.04.27

申请公布日期：2001.12.28

申请人：

ASTRAZENECA AB

发明人：ASHFORD MARIANNE;JAMES ROGER

分类号：C07D213/56;A61K31/496;A61P7/02;A61P43/00;C07D213/54

主分类号：C07D213/56

摘要：The invention relates to pharmaceutically acceptable salts of 1-(6-chloronaphth-2-ylsulphonyl)-4-[4-(4-pyridyl)benzoyl]piperazine and reduced particle size forms of either the compound or a pharmaceutically acceptable salt thereof, which possess antithrombotic and anticoagulant properties and accordingly are useful in methods of treatment of humans or animals. The invention also relates to processes for the preparation of pharmaceutically-acceptable salts of the above compound and reduced particle size forms thereof, to pharmaceutical compositions containing them and to their use in the manufacture of medicaments for use in the production of an antithrombotic or anticoagulant effect in humans.