MATERIALS AND METHODS RELATING TO A NOVEL SPLICE VARIANT OF A NA+ DEPENDENT GLUTAMATE TRANSPORTER,申请号GB2001001360-传众专利搜索

MATERIALS AND METHODS RELATING TO A NOVEL SPLICE VARIANT OF A NA+ DEPENDENT GLUTAMATE TRANSPORTER

申请公布号：WO2001073020(A1)

申请号：GB2001001360

申请日期：2001.03.26

申请公布日期：2001.10.04

摘要：<p>The invention relates to the Na+ dependent glutamate transporter GLAST-1 and a splice variant thereof. A novel splice variant has been found (GLAST-1a) which lacks exon 3 resulting in a loss of about 46 amino acids. The protein is altered in such a way that indicates altered function of the transporter. Indeed, the inventors have surprisingly determined that the splice variant has a reversed transport direction as compared to GLAST-1. Thus, the invention provides materials and methods relating to the splice variant GLAST-1a including the amino acid and nucleic acid sequence; materials and methods relating to the detection in vivo or in vitro of the GLAST-1a; and materials and methods relating to the modulation of excitatory amino acids (EAAs) signalling.</p>