SUBSTITUTED THIAZOLES FOR TREATMENT OF HUMAN DISEASES INVOLVING MODULATORS OF P-, L- AND E- SELECTIN,申请号WO1999US28694-传众专利搜索

SUBSTITUTED THIAZOLES FOR TREATMENT OF HUMAN DISEASES INVOLVING MODULATORS OF P-, L- AND E- SELECTIN

申请公布号：WO0034255(A9)

申请号：WO1999US28694

申请日期：1999.12.03

申请公布日期：2001.10.04

申请人：

ONTOGEN CORPORATION;NV ORGANON

发明人：INOUE, YOSHIMASA;JONES, TODD, KEVIN;KONDO, HIROSATO;NGUYEN, TRUC, NGOC;RAHEJA, RAJ, KUMAR;RIPKA, WILLIAM, CHARLES;SLEE, DEBORAH, HELEN;YU, JINGHUA

分类号：C07D233/54;C07D233/60;C07D277/30;C07D277/56;C07D401/04;C07D403/12;C07D413/10;C07D413/14;(IPC1-7):C07D277/30;C07D417/04;A61K31/427

主分类号：C07D233/54

摘要：Compounds of Formula (1) (where at least one of R<1>, R<2> or R<3> contains calcium binding moiety e.g. CO2H etc.) are disclosed. Where R<1> is typically a moiety containing a terminal carboxylic acid group such as cinnamic acid or phenoxy acetic acid, R<2> is typically a hydrophobic moiety such as functionalized alkyl chain or a functionalized aryl group, and R<3> is typically a functionalized aryl group, are within the scope of this invention. These compounds exhibit inhibitory activity against P-, L- and E-selectin and are indicated in the treatment of human diseases involving P-, L- and E-selectin.