Composto, composição farmacêutica e método para tratar ou inibir distúrbios associados com contração do músculo liso.

申请公布号：BR9915899(A)

申请号：BR19990015899

申请日期：1999.12.03

申请公布日期：2001.08.21

申请人：

AMERICAN HOME PRODUCTS CORPORATION

发明人：JOHN A. BUTERA;JOSEPH R. LENNOX;DOUGLAS J. JENKINS

分类号：A61K31/13;A61K31/135;A61K31/277;A61K31/44;A61K31/4406;A61P1/00;A61P13/02;A61P21/00;A61P21/02;A61P43/00;C07C225/20;C07C255/58;C07C271/24;C07D213/50;(IPC1-7):C07C261/00;C07D213/46;A61K31/132

主分类号：A61K31/13

摘要：COMPOSTO, COMPOSIçãO FARMACêUTICA E MéTODO PARA TRATAR OU INIBIR DISTúRBIOS ASSOCIADOS COM CONTRAçãO DO MúSCULO LISO". Desvreve-se 4-substituídas-3-substituídas-amino-ciclobut-3-eno-1,2-dionas possuindo a fórmula (I): onde R~ 1~, R~ 2~, R~ 3~, R~ 4~, R~ 5~, A e W são conforme definido na especificação, compostos esses que relaxam músculos lisos.

MASSELLI AUTOBLOCCANTI PER LA REALIZZAZIONE DI SELCIATI O SIMILI CON SUPERFICIE CALPESTABILE DISALLINEATA ATTA A DARE L'IMPRESSIONE DI SELCIATO REALIZZATO CON BLOCCHI FATTI A MANO

DISPOSITIVO PER IL VARO E L'ALAGGIO PER IMBARCAZIONI

EQUIPAGGIAMENTO PER PRODURRA MATTONI RUSTICI

SISTEMA PER LA DIAGNOSTICA ED IL COMANDO DI APPARATI DI GENERAZIONE E DISTRIBUZIONE DELLE ALIMENTAZIONI, IN PARTICOLARE PER IMPIANTI DI SICUREZZA E SEGNALAMENTO FERROVIARI

DISPOSITIVO E METODO PER RIVELARE LA PRESENZA E/0 IL MOVIMENTO DI UN FILO

PLASTIC SEMICONDUCTOR PACKAGE

METHOD FOR FABRICATING CIRCUIT DEVICE USING TWO LAMINATED CONDUCTIVE LAYERS

MECHANICAL AND THERMAL IMPROVEMENTS IN METAL HYDRIDE BATTERIES, BATTERY MODULES AND BATTERY PACKS

A SYSTEM FOR ANTIBODY EXPRESSION AND ASSEMBLY

PAINT COMPOSITION TO PROVIDE UNDER COAT WITH IMPROVED IMPACT RESISTANCE AND DRYNESS, WITHOUT OBSTRUCTING TOP COAT CURING, AND PAINTING METHOD USING THE SAME TO PROVIDE MULTILAYERED COAT WITHOUT PROBLEMS IN CURING

MULTIFUNCTIONAL PAPER USED AS WINDOW PAPER AND TWO-LAYERED UNDER PAPER

LEAD-COATED COMPLEX POROUS STRUCTURES, AND CORRESPONDING METHOD FOR CONDUCTIVE ACTIVATION

GLASS TERMINAL FOR IMPROVING TRANSMISSION CHARACTERISTIC OF HIGH-FREQUENCY SIGNAL

Method for production of cycloaliphatic compounds having side chain with epoxy groups by hydrogenizing on Ru-SiO2 latalyst

ADHERING METHOD FOR FIXING CHIP TO RESIN FILM AND ADHERING APPARATUS TO PREVENT GENERATION OF BUBBLES OR INFERIOR AGING DUE TO VOID

PLASTER FOR THE TREATMENT OF DYSFUNCTIONS AND DISORDERS OF NAILS

USE OF AN OIL OF THE GOURD FAMILY FOR INHIBITING 5$G(A)-REDUCTASE ACTIVITY

METHOD FOR JOINING PANELS USING PRE-APPLIED ADHESIVE

METHOD AND APPARATUS FOR GROWING PLANTS

NONWOVEN MATERIAL FOR LOW FRICTION BEARING SURFACES