Farmatseutiline kompositsioon ja selle kasutamine,申请号EE20000000232-传众专利搜索

Farmatseutiline kompositsioon ja selle kasutamine

申请公布号：EE200000232(A)

申请号：EE20000000232

申请日期：1998.11.10

申请公布日期：2001.06.15

申请人：

JANSSEN PHARMACEUTICA N.V.

发明人：MARC KAREL JOZEF FRANCOIS;WILLY MARIA ALBERT CARLO DRIES;ESTHER DINA GUIDO BASSTANIE

分类号：C07D471/04;A61K9/08;A61K9/14;A61K31/505;A61K31/506;A61K31/517;A61K31/519;A61P25/00;A61P25/18;A61P25/22;A61P25/24;A61P25/28;(IPC1-7):A61K9/08

主分类号：C07D471/04

摘要：<p>The present invention is concerned with a pharmaceutical composition suitable as a depot formulation for administration via intramuscular or subcutaneous injection, comprising: (1) as an active ingredient a therapeutically effective amount of a 9-hydroxy-risperidone fatty acid ester or a salt, or a stereoisomer or a stereoisomeric mixture thereof in submicron form and (2) a pharmaceutically acceptable carrier; wherein the pharmaceutically acceptable carrier is water and the active ingredient is suspended therein and with a process of preparing such a composition. The invention further concerns such a pharmaceutical composition for use as a medicament in the treatment of psychosis, schizophrenia, schizoaffective disorders, non-schizophrenic psychoses, behavioural disturbances associated with neurodegenerative disorders, e.g. in dementia, behavioural disturbances in mental retardation and autism, Tourette's syndrome, bipolar mania, depression, anxiety.</p>