DNA methyltransferase genomic sequences and antisense oligonucleotides,申请号US19980103875-传众专利搜索

DNA methyltransferase genomic sequences and antisense oligonucleotides

申请公布号：US6221849(B1)

申请号：US19980103875

申请日期：1998.06.24

申请公布日期：2001.04.24

申请人：

METHYLGENE, INC.

发明人：SZYF MOSHE;BIGEY PASCAL;RAMCHANDANI SHYAM

分类号：A01H5/00;A01K67/027;A61K31/711;A61K38/00;A61K48/00;A61P35/00;A61P43/00;C12N1/15;C12N1/19;C12N1/21;C12N5/10;C12N9/10;C12N15/09;C12N15/113;(IPC1-7):A61K31/708;A61K31/712;C07H21/04

主分类号：A01H5/00

摘要：The invention provides recombinant nucleic acids comprising nucleic acid sequences from the genomic DNA methyltransferase gene. The invention further provides sequence information for such nucleic acid sequences. In addition, the invention provides antisense oligonucleotides complementary to special regions of the genomic DNA methyltransferase gene or its RNA transcript. Finally, the invention provides methods for using such antisense oligonucleotides as analytical and diagnostic tools, as potentiators of transgenic plant and animal studies and gene therapy approaches, and as potential therapeutic agents.