NOVEL PROCESS,申请号WO2000EP08176-传众专利搜索

NOVEL PROCESS

申请公布号：WO0114369(A2)

申请号：WO2000EP08176

申请日期：2000.08.18

申请公布日期：2001.03.01

申请人：

SMITHKLINE BEECHAM P.L.C.;CROWE, DAVID;JONES, DAVID, ALAN

发明人：CROWE, DAVID;JONES, DAVID, ALAN

分类号：C07D405/12;(IPC1-7):C07D405/00

主分类号：C07D405/12

摘要：Paroxetine hydrochloride is prepared by subjecting (-)-trans-1-benzyl-4-(4-fluorophenyl)-3-(3,4-methylenedioxyphenoxymethyl) piperidine hydrochloride to catalytic hydrogenation in the presence of a noble metal catalyst in a solvent system consisting of either a mixture of propan-2-o1 and a co-solvent, such as acetic acid, or a solvent other than propan-2-o1, preferably ethanol or methanol, optionally with a co-solvent such as water or acetic acid. Use of this solvent system reduces the amount of residual starting material in the paroxetine hydrochloride product.