Polypeptide of human-origin hyaluronate synthetase and DNA encoding the same

申请公布号：US6162908(A)

申请号：US19980155768

申请日期：1998.10.05

申请公布日期：2000.12.19

申请人：

SEIKAGAKU CORPORATION

发明人：ITANO, NAOKI;KIMATA, KOJI

分类号：C12N9/10;C12N15/56;(IPC1-7):C12N9/26;C12N9/00

主分类号：C12N9/10

摘要：PCT No. PCT/JP97/01111 Sec. 371 Date Oct. 5, 1998 Sec. 102(e) Date Oct. 5, 1998 PCT Filed Mar. 31, 1997 PCT Pub. No. WO97/38113 PCT Pub. Date Oct. 16, 1997A DNA encoding at least part of a hyaluronan synthase of human origin, particularly encoding the whole or a part of an amino acid sequence shown by SEQ ID NO: 4. A polypeptide of the hyaluronan synthase of human origin, which is encoded by the DNA, may have a substitution, deletion or insertion of one or more amino acid residues that does not substantially lower an activity of synthesizing hyaluronan. A polypeptide of the hyaluronan synthase of human origin or a part thereof encoded by the DNA is also provided.

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