NEW CYCLOPROPYL DERIVATIVES, PREPARATION METHOD THEREOF AND APPLICATIONS.,申请号GR20000400676T-传众专利搜索

NEW CYCLOPROPYL DERIVATIVES, PREPARATION METHOD THEREOF AND APPLICATIONS.

申请公布号：GR3032976(T3)

申请号：GR20000400676T

申请日期：2000.03.16

申请公布日期：2000.07.31

申请人：

INSTITUTO DE INVESTIGACION Y DESARROLLO QUIMICO-BIOLOGICO S.A.

发明人：VERDE CASANOVA, MARIA JOSE;GALIANO RAMOS, ALVARO

分类号：C07D211/34;A61K31/00;A61K31/445;A61K31/4458;A61K31/4465;A61K31/451;A61P9/06;A61P23/00;A61P23/02;A61P25/02;C07D211/60;(IPC1-7):C07D211/34

主分类号：C07D211/34

摘要：<p>The new cyclopropyl derivatives have formula (I) wherein R is cyclopropyl or methylcyclopropyl. The preparation process comprises reacting 2,6-dibromohexanoyl chloride with 2,6-dimethylanyline in the presence of a base at 0 DEG -25 DEG C to give 2,6-dibromohexanoyl-2,6-dimethylanilide which subsequently is caused to react with R-NH2 (wherein R is as defined hereabove) at 70-100 DEG C to give the cyclopropyl derivatives having formula (I). The compounds (I) can be applied as antiarithmic agents and as local anaesthetic agents. <CHEM></p>