METHOD FOR ASSESSING A DIABETIC'S RISK OF EXPERIENCING A DIABETES-ASSOCIATED PATHOLOGIC CONDITION
申请公布号:WO9964561(A2)
申请号:WO1999US13122
申请日期:1999.06.10
申请公布日期:1999.12.16
发明人:BROWN, TRUMAN, R.;KAPPLER, FRANCIS;SZWERGOLD, BENJAMIN;LAL, SUNDEEP;SU, BANGYING
分类号:G01N33/50;G01N33/66
主分类号:G01N33/50
摘要:Disclosed is a class of compounds which inhibit the enzymatic conversion of fructose-lysine into fructose-lysine-3-phosphate in an ATP dependent reaction in a newly discovered metabolic pathway. According to the normal functioning on this pathway, fructose-lysine-3-phosphate (FL3P) is broken down to form free lysine, inorganic phosphate and 3-deoxyglucosone (3DG), the latter being a reactive protein modifying agent. 3DG can be detoxified by reduction to 3-deoxyfructose (3DF), or it can react with endogenous proteins to form advanced glycation end-product modified proteins (AGE-proteins), which are believed to be a contributing cause of diabetic complications. Also disclosed are therapeutic methods of using such inhibitors to reduce formation of AGE-proteins and thereby lessen, reduce and delay diabetic complications, as well as methods for assessing a diabetic's risk of developing complications and for determining the efficacy of the disclosed inhibitor therapy by measuring the ratio of 3DG to 3DF in a biological sample following an oral dose of a fructose-lysine-containing food product.
ARRANGEMENT FOR TAKING CARBON DIOXIDE BATHS
DEVICE FOR THERMOGRAPHY OF THE TONGUE MUCOUS MEMBRANE
DEVICE FOR FIXING ECHOCARDIOGRAPH TRANSDUCER
BRIDGE UNIT FOR AGRICULTURAL JOBS
RALENTISSEUR ELECTROMAGNETIQUE, MOYENS D'ALIMENTATION ASSOCIES ET APPLICATION A UN VEHICULE
GLASS AMPOULE OR BOTTLE, AND ITS PRODUCTION
HIGH-FREQUENCY MOLDING PROCESS
BUILDING MATERIAL OF PANEL FOR LIVESTOCK BARN
ALUMINUM FOIL AS ELECTRODES OF AN ELECTROLYTIC CAPACITOR
DATA TRANSFER CONTROL CIRCUIT AND DYNAMIC TYPE SEMICONDUCTOR USING THIS CIRCUIT