SYSTEM FOR REPRODUCING AND MODULATING STABILITY AND TURNOVEROF RNA MOLECULES,申请号CA19992329513-传众专利搜索

SYSTEM FOR REPRODUCING AND MODULATING STABILITY AND TURNOVEROF RNA MOLECULES

申请公布号：CA2329513(A1)

申请号：CA19992329513

申请日期：1999.05.26

申请公布日期：1999.12.02

申请人：

UNIVERSITY OF MEDICINE AND DENTISTRY OF NEW JERSEY

发明人：WILUSZ, JEFFREY;FORD, LANCE P.

分类号：C12N15/09;C12N5/22;C12N15/10;C12P19/34;C12Q1/68;C40B40/02;(IPC1-7):C12N15/10

主分类号：C12N15/09

摘要：An in vitro system is provided that recapitulates regulated mRNA stability a nd turnover of exogenous RNA substrates. The system comprises a cell extract optionally depleted of activity of proteins that bind polyadenylate, and a target RNA sequence. This system is used for the identification of agents capable of modulating RNA turnover, as well as agents capable of modulating RNA turnover in the presence of RNA stability modifying agents.