WATER-SOLUBLE COUMARIN FLUORESCENT ENZYME SUBSTRATES

申请公布号：CA2322205(A1)

申请号：CA19992322205

申请日期：1999.03.10

申请公布日期：1999.09.16

申请人：

ABBOTT LABORATORIES

发明人：VENKATA, SESHAGIRI R. TATA;MULLEN, CAROLYN R.;HUFF, JEFFREY B.;MERCHANT, BARBARA T.

分类号：C07D311/16;C07D311/18;C07H17/075;C12Q1/34;C12Q1/42;(IPC1-7):C12Q1/34

主分类号：C07D311/16

摘要：Fluorescent enzyme substrates are provided. The substrates are derivatives of coumarin having an enzyme cleavable group at position 7 and a hydrophilic amide group at position 4. The compounds are highly water soluble, stable at ambient and reduced temperatures and fluoresce upon cleavage by an enzyme.

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