Keratan sulfate oligosaccharide fraction and pharmaceutical containing the same,申请号US19970849925-传众专利搜索

Keratan sulfate oligosaccharide fraction and pharmaceutical containing the same

申请公布号：US5939403(A)

申请号：US19970849925

申请日期：1997.06.02

申请公布日期：1999.08.17

申请人：

SEIKAGAKU CORPORATION

发明人：MARUYAMA, HIROSHI;MORIKAWA, KIYOSHI;TAWADA, AKIRA;MIYAUCHI, SATOSHI;YOSHIDA, KEIICHI;ASARI, AKIRA

分类号：A61K31/737;C07H11/00;C07H13/04;C08B37/00;C12P19/26;(IPC1-7):A61K31/73;A61K31/725;C08B3/04;C08B3/06

主分类号：A61K31/737

摘要：PCT No. PCT/JP95/02386 Sec. 371 Date Jun. 2, 1997 Sec. 102(e) Date Jun. 2, 1997 PCT Filed Nov. 22, 1995 PCT Pub. No. WO96/16973 PCT Pub. Date Jun. 6, 1996A keratan sulfate oligosaccharide which comprises from two to five sugar units and has sulfated N-acetylglucosamine at the reducing end and in a molecule of which at least two hydroxyl groups are sulfated, preferably, which contains at least disaccharide represented by the formula Gal(6S)-GlcNAc(6S) (in the formula, Gal, GlcN, Ac, and 6S represent a galactose, a glucosamine, an acetyl group, and a 6-O-sulfate ester, respectively) as a constitutional ingredient, and/or pharmaceutically acceptable salt thereof are used as active ingredients of anti-inflammatory agents, antiallergic agents, immunomodulators, cell differentiation inducers, and apoptosis inducers.