METHOD OF SYNTHESIS OF (S)-<EMI ID=0.552 HE=3 WI=9 TI=CHI>-N,N-DIMETHYL-3-(1-NAPHTHALINYL- -HYDROXY)-3-(2-THIENYL)-PROPANEAMINE AND (S)-<EMI ID=0.553 HE=3 WI=3 TI=CHI>-N,N-DIMETHYL- -3-(1-NAPHTHALINYLHYDROXY)-3-(2-THIENYL)-PROPANEAMINE PHOSPHATE,申请号RU19940035996-传众专利搜索

METHOD OF SYNTHESIS OF (S)-<EMI ID=0.552 HE=3 WI=9 TI=CHI>-N,N-DIMETHYL-3-(1-NAPHTHALINYL- -HYDROXY)-3-(2-THIENYL)-PROPANEAMINE AND (S)-<EMI ID=0.553 HE=3 WI=3 TI=CHI>-N,N-DIMETHYL- -3-(1-NAPHTHALINYLHYDROXY)-3-(2-THIENYL)-PROPANEAMINE PHOSPHATE

申请公布号：RU2127269(C1)

申请号：RU19940035996

申请日期：1994.10.06

申请公布日期：1999.03.10

申请人：

EHLI LILLI EHND KOMPANI

发明人：RICHARD ALAN BERGLAND

分类号：C07D333/20;C01B25/26;C07B53/00;C07D333/16;(IPC1-7):C07D333/20

主分类号：C07D333/20

摘要：FIELD: organic chemistry, chemical technology, pharmaceutical chemistry. SUBSTANCE: invention relates to asymmetric process of synthesis of key intermediate compound used for synthesis of antidepressant agent dulonectin. Method of synthesis of the above indicated compound involves interaction of (S)-(-)- -N, N-dimethyl-3-(2-thienyl)-3-hydroxypropaneamine with sodium hydride and 1-fluoronaphthalene in an organic solvent. Process is carried out using potassium benzoate or acetate and the end product is isolated as a free form or if necessary as phosphate. EFFECT: accelerated process, enhanced purity, increased yield of the end product. 6 cl, 2 ex