Stimulating the differentiation of predipocytic cells and therapies based thereon,申请号US19970787216-传众专利搜索

Stimulating the differentiation of predipocytic cells and therapies based thereon

申请公布号：US5827897(A)

申请号：US19970787216

申请日期：1997.01.22

申请公布日期：1998.10.27

申请人：

CENTRE INTERNATIONAL DE RECHERCHES DERMATOLOGIQUES GALDERMA

发明人：AILHAUD, GERALD;GRIMALDI, PAUL;SAFONOVA, IRINA;SHROOT, BRAHAM;REICHERT, UWE

分类号：A61K35/60;A61K31/07;A61K31/19;A61K31/195;A61K31/20;A61K31/201;A61K31/202;A61K31/203;A61K35/64;A61K36/18;A61K45/00;A61P3/02;A61P3/06;A61P3/08;A61P3/10;A61P9/10;A61P9/12;A61P43/00;(IPC1-7):A61K31/07;A61K31/215;A61K31/22

主分类号：A61K35/60

摘要：The differentiation of preadipocytic cells into adipocytic cells, in particular for correcting insulin-resistance disease states in mammalian organisms, notably in humans, for example type II diabetes and cardiovascular disorders such as hypertension and atherosclerosis, is stimulated by treating such preadipocytic cells, or a patient in need of such treatment, with an effective amount of (a) at least one ligand displaying affinity for the nuclear receptors for retinoic acid and/or isomers thereof, preferably at least one ligand displaying a specific affinity for the RAR receptors and even more preferably the RAR- alpha receptor and (b) at least one fatty acid, e.g., a polyunsaturated fatty acid.