MONOCLONAL ANTIBODIES THAT DEFINE UNIQUE MENINGOCOCCAL B EPITOPES AND THEIR USE IN THE PREPARATION OF VACCINE COMPOSITIONS,申请号CA19972264585-传众专利搜索

MONOCLONAL ANTIBODIES THAT DEFINE UNIQUE MENINGOCOCCAL B EPITOPES AND THEIR USE IN THE PREPARATION OF VACCINE COMPOSITIONS

申请公布号：CA2264585(A1)

申请号：CA19972264585

申请日期：1997.08.27

申请公布日期：1998.03.05

申请人：

CHIRON CORPORATION;CHILDREN'S HOSPITAL MEDICAL CENTER OF NORTHERN CALIFORNIA

发明人：GRANOFF, DAN;MOE, GREGORY R.

分类号：C12N15/02;A61K39/00;A61K39/095;A61P31/04;C07K7/06;C07K14/22;C07K16/12;C07K16/42;C12N5/10;C12P21/08;G01N33/569;(IPC1-7):C12N5/18;A61K48/00;A61K39/40;G01N33/53;A61K31/70

主分类号：C12N15/02

摘要：Novel bactericidal antibodies against Neisseria meningitidis serogroup B ("MenB") are disclosed. The antibodies either do not cross-react or minimally cross-react with host tissue polysialic acid and hence pose minimal risk of autoimmune activity. The antibodies are used to identify molecular mimetics of unique eptitopes found on MenB or E. coli K1. Examples of such peptide mimetics are described that elicit serum antibody capable of activating complement-mediated bacteriolysis of MenB. Vaccine compositions containing such mimetics can be used to prevent MenB or E. coli K1 disease without the risk of evoking autoantibody.