Method of lowering serum cholesterol levels with 2,6-di-alkyl-4-silyl-phenols,申请号US19960582835-传众专利搜索

Method of lowering serum cholesterol levels with 2,6-di-alkyl-4-silyl-phenols

申请公布号：US5677291(A)

申请号：US19960582835

申请日期：1996.01.02

申请公布日期：1997.10.14

申请人：

HOECHST MARION ROUSSEL, INC.

发明人：MAO, SIMON J. T.;YATES, MARK T.;PARKER, ROGER A.

分类号：A61K31/695;C07F7/08;(IPC1-7):A61K31/695;C07F7/18

主分类号：A61K31/695

摘要：A method of lowering plasma cholesterol level in a patient with hypercholesterolemia, by administration of a compound of formula (1) <IMAGE> wherein: R1, R2, R3 and R4 are each independently a C1-C6 alkyl group; Z is a thio, oxy or methylene group; A is a C1-C4 alkylene group; and R5 is a C1-C6 alkyl or -(CH2)n-(Ar) wherein n is an integer 0, 1, 2 or 3; and Ar is phenyl or napthyl unsubstituted or substituted with one to three substituents selected from the group consisting of hydroxy, methoxy, ethoxy, chloro, fluoro or C1-C6 alkyl.