CONOTOXIN PEPTIDE PVIIA,申请号CA19972248710-传众专利搜索

CONOTOXIN PEPTIDE PVIIA

申请公布号：CA2248710(A1)

申请号：CA19972248710

申请日期：1997.03.14

申请公布日期：1997.09.25

申请人：

UNIVERSITY OF UTAH RESEARCH FOUNDATION;MAX-PLANCK-INSTITUT FUER EXPERIMENTELLE MEDIZIN

发明人：TERLAU, HEINRICH;OLIVERA, BALDOMERO M.;GRILLEY, MICHELLE M.;SHON, KI-JOON

分类号：A61K38/00;C07K14/435;(IPC1-7):C07K14/435

主分类号：A61K38/00

摘要：A new peptide, -conotoxin PVIIA, is disclosed. This peptide is found naturally in the cone snail Conus purpurascens and has the amino acid sequence Cys-Arg-Ile-Xaa-Asn-Gln-Lys-Cys-Phe-Gln-His-Leu-Asp-Asp-Cys-Cys-Ser-Arg-Lys-Cys-Asn-Arg-Phe-Asn-Lys-Cys-Val (SEQ ID NO:1) where Xaa represents 4-trans-hydroxyproline, hydroxyproline or proline. This peptide together with a previously disclosed peptide, .delta.-conotoxin PVIA, act synergistically to rapidly immobilize fish which are injected with the two peptides. Injection of -conotoxin PVIIA alone results in different symptoms with an injected fish becoming hyperactive and then contracting and suddenly extending all major fins. This "fin-popping" occurs repeatedly resulting in a series of jerky movements, but injection of only -conotoxin PVIIA does not immobilize or kill the fish.