Fusion protein delivery system and uses thereof,申请号AU19960054828-传众专利搜索

Fusion protein delivery system and uses thereof

申请公布号：AU5482896(A)

申请号：AU19960054828

申请日期：1996.04.12

申请公布日期：1996.10.30

申请人：

UNIVERSITY OF ALABAMA RESEARCH FOUNDATION

发明人：JOHN CHRISTOPHER KAPPES;XIAOYUN WU

分类号：A61K38/00;A61K47/48;C07K14/16

主分类号：A61K38/00

摘要：The present invention provides a composition of matter, comprising: DNA encoding a viral Vpx protein fused to DNA encoding a protein. In another embodiment of the present invention, there is provided a composition of matter, comprising: DNA encoding a viral Vpr protein fused to DNA encoding a protein. The present invention further provides DNA, vectors and methods for expressing a lentiviral pol gene in trans, independent of the lentiviral gag-pol. A gene transduction element is optionally delivered to a lentiviral vector according to the present invention. Also provided are various methods of delivering a virus inhibitory molecule to a target in an animal. Further provided is a pharmaceutical composition.