Submicron emulsions as ocular drug delivery vehicles,申请号US19930000854-传众专利搜索

Submicron emulsions as ocular drug delivery vehicles

申请公布号：US5496811(A)

申请号：US19930000854

申请日期：1993.01.05

申请公布日期：1996.03.05

申请人：

PHARMOS CORP.

发明人：AVIV, HAIM;FRIEDMAN, DORON;BAR-ILAN, AMIR;VERED, MICHA

分类号：A61K9/00;A61K9/107;(IPC1-7):A61K31/685;A61K31/66;A61K31/22;A61K31/225

主分类号：A61K9/00

摘要：An ocular drug delivery vehicle of an oil-in-water submicron emulsion comprising about 0.5 to 50% of a first component of an oil, about 0.1 to 10% of a second component of an emulsifier, about 0.05 to 5% of a non-ionic surfactant and an aqueous component, with the mean droplet size being in the submicron range, i.e., below about 0.5 mu m and preferably between about 0.1 and 0.3 mu m. Also, topical pharmaceutical compositions containing a drug such as an anti-glaucoma drug, beta adrenergic blocker or other autonomic system drug, a local anesthetic, a steroid, a non-steroidal anti-inflammatory drug, an antibiotic drug, an antifungal drug, an antiviral drug or combinations thereof and the vehicle described above. Methods of administering such vehicles or compositions to the eye of a patient while reducing irritation thereof and providing increased bioavailability of the drug.