Storage stable calcium phosphate cements,申请号US19940294325-传众专利搜索

Storage stable calcium phosphate cements

申请公布号：US5496399(A)

申请号：US19940294325

申请日期：1994.08.23

申请公布日期：1996.03.05

申请人：

NORIAN CORPORATION

发明人：ISON, IRA C.;FULMER, MARK T.;BARR, BRYAN M.;CONSTANTZ, BRENT R.

分类号：A61F2/00;A61L27/12;C04B12/02;C04B20/10;C04B28/34;C04B40/06;(IPC1-7):C04B12/02

主分类号：A61F2/00

摘要：Two component, storage stable apatitic cement compositions, as well as methods for their production, are provided. The dry component of subject apatitic cements comprises basic calcium source particles at least partially coated with a partially neutralized acidic calcium phosphate. The dry component of subject compositions is prepared by combining basic calcium source particles with dissolved acidic phosphate in at least a partially aqueous medium, whereby the basic calcium source particles become partially coated with a partially neutralized acidic calcium phosphate. The reaction is terminated prior to completion of the reaction between the acidic phosphate and the basic calcium source by removing the available water from the reaction mixture. In a first mode, the subject cement may be produced by mechanically mixing an acidic phosphate source with basic calcium source particles in the presence of an aqueous solvent and stopping the reaction between the acid and base prior to completion. Alternatively, a phosphoric acid solution may be rapidly combined with a basic calcium phosphate particle slurry such that partially neutralized acidic calcium phosphate precipitates on the surface of the basic calcium phosphate particles.