INHIBITION OF DNA METHYLTRANSFERASE,申请号WO1994CA00659-传众专利搜索

INHIBITION OF DNA METHYLTRANSFERASE

申请公布号：WO9515373(A3)

申请号：WO1994CA00659

申请日期：1994.11.30

申请公布日期：1995.08.10

申请人：

MCGILL UNIVERSITY;SZYF, MOSHE

发明人：SZYF, MOSHE

分类号：C12N15/09;A61K31/70;A61K38/00;A61K38/43;A61K39/395;A61K48/00;A61P7/06;A61P35/00;C07H21/04;C07K16/40;C12N9/00;C12N9/10;C12N15/113

主分类号：C12N15/09

摘要：The present invention relates to the interplay between the level of DNA methyltransferase and demethylase activities, to the role of the interplay between these levels on the proliferative, differentiated, tumorigenic and homeostatic state of the cell, and to the DNA methyltransferase and demethylase as therapeutic targets. The invention further relates to a reduction of the level of DNA methylation through inhibitors and antagonist in order to inhibit the excessive activity or hypermethylation of DNA MeTase in cancer cells to induce the original cellular tumor suppressing program, to turn on alternative gene expression programs, to provide therapeutics directed at a nodal point of regulation of genetic information, and to modulate the general level of methylase and demethylase enzymatic activity of a cell to permit specific changes in the methylation pattern of a cell (Fig. 1). <IMAGE>