Process for the production of peptides by solid phase synthesis.,申请号GR19950400517T-传众专利搜索

Process for the production of peptides by solid phase synthesis.

申请公布号：GR3015359(T3)

申请号：GR19950400517T

申请日期：1995.03.10

申请公布日期：1995.06.30

申请人：

HOECHST AKTIENGESELLSCHAFT

发明人：BREIPOHL, GERHARD, DR.;KNOLLE, JOCHEN, DR.;KOENIG, WOLFGANG, DR.

分类号：C07K1/04;C07K1/06;C07K1/10;C07K1/113;C07K7/06;(IPC1-7):C07K1/04

主分类号：C07K1/04

摘要：<p>A process for the production of peptides of the formula (X)n-A-NH2 in which X is a natural or unnatural amino acid, azaamino acid or imino acid, n is an integer from 1 to 50, preferably 1 to 30, and A is an azaamino acid, and the physiologically tolerated salts thereof is described and is characterised in that a spacer is converted into a form which can be acylated, and the latter is reacted with a suitable formic acid derivative and subsequently with an appropriate amino acid hydrazide, where appropriate the protective group is converted into a protective group which is base-labile or labile to weak acids, the spacer obtained in this way is coupled to a resin, the required peptide is built up stepwise from the C-terminal end, and subsequently the peptide is cleaved off the resin and, where appropriate, converted into its physiologically tolerated salts.</p>