METHOD OF CLEAVING SPECIFIC STRANDS OF RNA

申请公布号：CA2147282(A1)

申请号：CA19932147282

申请日期：1993.10.20

申请公布日期：1994.04.28

申请人：

CLEVELAND CLINIC RESEARCH INSUITUTE (THE)

发明人：LESIAK, KRYSTYNA;SILVERMAN, ROBERT;TORRENCE, PAUL;MAITRA, RATAN

分类号：C12N15/09;C07H21/00;C07H21/02;C12N9/16;C12N15/113;(IPC1-7):C12N15/10;A61K31/70

主分类号：C12N15/09

摘要：A method of using a chimeric molecule made up of an antisense oligonucleotide attached to a 2',5'-oligoadenylate molecule to specifically cleave a sense strand of RNA, wherein the antisense oligonucleotide of the chimeric molecule is hybridized to the sense strand of RNA in the presence of 2', 5'-dependent RNase.

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