Biphenyl derivatives pharmaceutical compositions containing the same and processes for the preparation thereof,申请号IL19930108067-传众专利搜索

Biphenyl derivatives pharmaceutical compositions containing the same and processes for the preparation thereof

申请公布号：IL108067(D0)

申请号：IL19930108067

申请日期：1993.12.17

申请公布日期：1994.04.12

申请人：

SANKYO COMPANY LIMITED

分类号：A61K31/415;A61K31/41;A61K31/4164;A61K31/4184;A61K31/4188;A61K31/435;A61K31/44;A61K31/4418;A61K31/4427;A61K31/505;A61P9/00;A61P9/12;A61P43/00;C07D213/60;C07D213/80;C07D233/58;C07D233/64;C07D233/68;C07D233/70;C07D233/88;C07D233/90;C07D233/92;C07D235/04;C07D235/08;C07D235/14;C07D235/26;C07D239/42;C07D401/10;C07D401/12;C07D403/04;C07D403/10;C07D405/12;C07D471/04;(IPC1-7):C07D

主分类号：A61K31/415

摘要：<p>Compounds of formula (I) : <CHEM> [wherein: A represents a group (IIa), (IIb) or (IIc) : <CHEM> <CHEM> R<1> is alkyl, alkenyl, cycloalkyl or a group of formula R<4>-Y-R<5>-, where: R<4> is hydrogen, alkyl, or cycloalkyl, R<5> is a single bond or alkylene, and Y is oxygen, sulphur or imino group; R<2> is hydrogen, halogen, Optionally substituted alkyl, optionally substituted alkenyl, optionally substituted cycloalkyl, hydroxy, amino, alkylamino, dialkylamino, formyl, alkylcarbonyl, alkoxy, alkylthio, cyano or nitro; R<3> is hydrogen, alkyl, carboxy, protected carboxy, carbamoyl or tetrazol-5-yl; X is of formula -CH=, -N= or -C(COOR<6>)=, where R<6> is hydrogen or a carboxy-protecting group; Z is a single bond, alkylene or vinylene; and B is carboxy, protected carboxy or tetrazol-5-yl]; and pharmaceutically acceptable salts and esters thereof have the ability to inhibit the action of angiotensin II and thus can be used for the treatment and prophylaxis of hypertension and cardiac iseases.</p>