Methods for reducing bone loss using centchroman derivatives,申请号US19930029729-传众专利搜索

Methods for reducing bone loss using centchroman derivatives

申请公布号：US5280040(A)

申请号：US19930029729

申请日期：1993.03.11

申请公布日期：1994.01.18

申请人：

ZYMOGENETICS, INC.

发明人：LABROO, VIRENDER M.;PIGGOTT, JAMES R.;BAIN, STEVEN D.

分类号：C07D311/58;A61K31/35;A61K31/352;A61K31/40;A61K31/4025;A61K31/55;A61P19/10;(IPC1-7):A61K31/40

主分类号：C07D311/58

摘要：Methods and pharmaceutical compositions for reducing bone loss are disclosed. 3,4-diarylchromans and their pharmaceutically acceptable salts are formulated into medicaments for the treatment of bone loss due to osteoporosis or other conditions. An exemplary 3,4-diarylchroman is centchroman (3,4-trans-2,2-dimethyl-3-phenyl-4-(p-(beta-pyrrolidinoethoxy)phenyl)-7-methoxy-chroman). Formulations include tablets and other forms suitable for oral administration and controlled-release subdermal implants.