DNA SEQUENCE CAPABLE OF CODING RABBIT CORTICOSTATIN

申请公布号：JPH05244954(A)

申请号：JP19920048626

申请日期：1992.03.05

申请公布日期：1993.09.24

申请人：

NIPPON STEEL CORP;NIPPON STEEL CHEM CO LTD

发明人：ISOHARA TOSHIO;HAYASHI YOSHIO

分类号：A61K35/12;A61K35/28;A61K35/42;A61K38/00;A61P31/04;C07K14/00;C12N15/09;C12N15/12;C12N15/62;C12N15/70;(IPC1-7):C12N15/12;A61K37/02

主分类号：A61K35/12

摘要：PURPOSE:To obtain a new DNA sequence capable of expressing a rabbit corticostatin having an antagonistic action on an adrenocorticotrophic hormone (ACTH) in a microbial cell. CONSTITUTION:The objective DNA sequence capable of coding a rabbit corticostatin having a base sequence of the formula. The DNA sequence capable of coding the rabbit corticostatin with a highly frequently used codon of Escherichia coli is constructed by synthesizing each fragment with a DNA synthesizer, etc., and purifying only a DNA sequence of a complete length with high-performance liquid chromatography(HPLC), etc.

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