PRODUCTION OF 2-FLUROISOBUTYRIC ACID ESTER,申请号JP19920009358-传众专利搜索

PRODUCTION OF 2-FLUROISOBUTYRIC ACID ESTER

申请公布号：JPH0543515(A)

申请号：JP19920009358

申请日期：1992.01.22

申请公布日期：1993.02.23

申请人：

IDEMITSU KOSAN CO LTD

发明人：TERADA IZUMI;NISHII MASAHIRO

分类号：B01J27/08;B01J31/02;C07B61/00;C07C67/307;C07C69/63

主分类号：B01J27/08

摘要：PURPOSE:To obtain a 2-fluoroisobutyric acid ester useful as an intermediate for a triazine-type herbicide from a methacrylic acid ester with single reaction step in high yield at a low cost. CONSTITUTION:The objective 2-fluoroisobutyric acid ester is produced on an industrial scale at a low cost by reacting a methacrylic acid ester, e.g. a compound of formula I (R is alkyl, aryl, aralkyl or alkoxyalkyl) with (a) preferably an essentially anhydrous hydrogen fluoride source such as hydrogen fluoride and (b) an amine such as aromatic amine (e.g. pyridine, melamine or collidine) or tertiary aliphatic amine (e.g. trimethylamine or tributylamine) at a weight ratio (a/b) of usually 50/50 to 99/1, preferably 70/30 to 95/5 in the presence of preferably a Lewis acid catalyst preferably at 20-150 deg.C especially 50-120 deg.C. The compound is useful as an intermediate for the compound of formula II having excellent herbicidal effect, etc., and free from phytotoxicity to paddy rice plant.