HUMANISED ANTIBODIES,申请号CA19912037607-传众专利搜索

HUMANISED ANTIBODIES

申请公布号：CA2037607(A1)

申请号：CA19912037607

申请日期：1991.03.06

申请公布日期：1992.09.07

申请人：

ADAIR, JOHN R.;ATHWAL, DILJEET S.;EMTAGE, JOHN S.

发明人：ADAIR, JOHN R.;ATHWAL, DILJEET S.;EMTAGE, JOHN S.

分类号：A61K39/395;A61K;A61K38/00;A61K49/00;A61P37/00;C07K14/435;C07K14/52;C07K14/525;C07K14/725;C07K16/00;C07K16/18;C07K16/24;C07K16/28;C07K16/42;C07K16/46;C07K19/00;C12N;C12N5/10;C12N15/09;C12N15/13;C12P21/00;C12P21/02;C12P21/08;C12Q;C12R1/91;G01N33/53;G01N33/577;(IPC1-7):C12N15/13

主分类号：A61K39/395

摘要：CDR-grafted antibody heavy and light chains comprise acceptor framework and donor antigen binding regions, the heavy chains comprising donor residues at at least one of positions 6, 23 and/or 24, 48 and/or 49, 71 and/or 73, 75 and/or 76 and/or 78 and 88 and/or 91. The CDR-graftd light chains comprise donor residues at at least one of positions 1 and/or 3 and 46 and/or 47 or at at least one of positions 46, 48, 58 and 71. The CDR-grafted antibodies are preferably humanised antibodies, having non human, e.g. rodent, donor and human acceptor frameworks, and may be used for in vivo therapy and diagnosis. A generally applicable protocol is disclosed for obtaining CDR-grafted antibodies.