,申请号JP19890054880-传众专利搜索

申请公布号：JPH0439998(B2)

申请号：JP19890054880

申请日期：1989.03.09

申请公布日期：1992.07.01

申请人：

DENKI KAGAKU KOGYO KK

发明人：HASHIMOTO MASAMICHI;CHIBA SUSUMU;SAEGUSA HARUHISA;KITAGAWA HIROYUKI;MYOSHI TERUZO

分类号：C12P19/26;C12R1/46

主分类号：C12P19/26

摘要：PURPOSE:To obtain hyaluronic acid in high yield stably by culturing FM300, a mutant of Streptococcus equi. CONSTITUTION:A nutrition-requiring mutant of Streptococcus equi, FM300 (FERM No. 2319) is inoculated in a usual medium and cultured at 6.5 to 9.0pH and 30 to 35 deg.C, the culture mixture is centrifuged to remove cell bodies. Then, the supernatant is treated with an organic solvent such as alcohol or the like to effect precipitation and ultrafiltration is carried out to effect desalination whereby hyaluronic acid is obtained.