PHOSPHOLIPASE A2 INHIBITOR,申请号JP19900285597-传众专利搜索

PHOSPHOLIPASE A2 INHIBITOR

申请公布号：JPH04158790(A)

申请号：JP19900285597

申请日期：1990.10.22

申请公布日期：1992.06.01

申请人：

SHIONOGI & CO LTD

发明人：YOSHIDA TADASHI;MATSUTANI SHIGERU;KAWAMURA YOSHIMI;MATSUMOTO KOICHI

分类号：C12P17/06;A61K31/35;A61K31/352;A61P43/00;C07D311/80;C12R1/645

主分类号：C12P17/06

摘要：NEW MATERIAL:A compound shown by the formula. The compound has three kinds of isomers and one of the compounds has the following physical and chemical properties. Molecular formula: C64H70O21. Melting point: 203-206 deg.C. Appearance: colorless powder. SIMS (m/z): 1,175 (MH<+>). HRMS (m/z): 1,175.4488 (MH<+>). Solubility: soluble in dimethyl sulfoxide, methanol, chloroform and ethyl acetate and insoluble in n-hexane, ether, petroleum ether and water. Color reaction: positive in FeCl3 and negative in ninhydrin, SAKAGUCHI and Ehrlich. Elemental analysis: (%): C 64.09, H 6.35, etc. USE:A phospholipase A2 inhibitor. PREPARATION:A strain such as Thielavia terricola FR-143 (FERM BP-2,196) belonging to the genus Thielavia is cultured preferably at 28 deg.C for 1-10 days while aerating and stirring.