Protein A perfusion and post perfusion drug infusion,申请号US19900563940-传众专利搜索

Protein A perfusion and post perfusion drug infusion

申请公布号：US5091091(A)

申请号：US19900563940

申请日期：1990.08.06

申请公布日期：1992.02.25

申请人：

TERMAN, DAVID S.

发明人：TERMAN, DAVID S.

分类号：A61K39/385;A61M1/34

主分类号：A61K39/385

摘要：Disclosed is extracorporeal plasma perfusion over a therapeutic immobilized protein A (staphylococcal), SPA. The perfused plasma is returned to the host or can be taken off one person and used to treat another and stored in perfused plasma banks. Immobilized protein A quantities, volumes of plasma perfused and the rate of administration based on clinical and toxicity evaluations are set forth. A non-toxic drug infusion during the immediate postperfusion period obtains an observed tumoricidal response far exceeding those due to the extracorporeal plasma perfusion or drug infusion alone representing an in vivo synergism between the perfused plasma and the drug. Also disclosed are the therapeutic protein A cartridge, its loading and delivery system, and a miniaturized immunoabsorbent apparatus enabling the processing of serum samples for testing small quantities of plasma.