INSECT RETINOID RECEPTOR COMPOSITIONS AND METHODS,申请号US1991001894-传众专利搜索

INSECT RETINOID RECEPTOR COMPOSITIONS AND METHODS

申请公布号：WO1991014695(A1)

申请号：US1991001894

申请日期：1991.03.21

申请公布日期：1991.10.03

摘要：<p>The present invention relates to the discovery of novel insect receptor polypeptides, which modulate transcription of certain genes by binding to cognate response elements. The novel receptors of the invention are activated when the cells are exposed to retinoic acid. The invention provides DNAs encoding the novel receptors; expression vectors; cells transformed with such expression vectors; cells co-transformed with such expression vectors and with test vectors to monitor activation of the receptors to modulate transcription; and methods of using such co-transformed cells in screening for compounds which are capable of activation of the receptors and for compounds capable of interfering with such activation as potential potent insecticides. The invention also provides DNA and RNA probes for identifying DNA's encoding retinoid receptors of insects and other animals as shown in the figure, to which the novel receptors of the invention belong.</p>