1,2,4-BENZOTRIAZINE OXIDES AS RADIOSENSITIZERS AND SELECTIVE CYTOTOXIC AGENTS.

申请公布号：EP0413706(A1)

申请号：EP19890904704

申请日期：1989.03.15

申请公布日期：1991.02.27

申请人：

SRI INTERNATIONAL

发明人：LEE, WILLIAM, W.;BROWN, J., MARTIN;GRANGE, EDWARD, W.;MARTINEZ, ABELARDO, P.;TRACY, MICHAEL

分类号：C07D253/08;A61K31/53;A61K31/5377;A61K41/00;A61P35/00;C07D253/10

主分类号：C07D253/08

摘要：L'invention concerne un procédé d'utilisation d'oxydes de 1,2,4-benzotriazine en tant qu'agents radiosensibilisateurs et en tant qu'agents cytotoxiques sélectifs. Les composés ont une radiosensibilité spécifique aux cellules tumorales hypoxiques et sont utiles comme agents cytotoxiques spécifiques pour ces cellules.

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